// Evidence Grader
Claim grades, A through F
Every major genomics claim in this course gets a transparent grade — from clinically established interventions to outright misleading marketing. Use this dashboard to audit what's settled, what's preliminary, and what's hype.
A
Clinically established
B
Supported, context-specific
C
Promising, preliminary
D
Plausible, unproven
E
Popular, weak support
F
Misleading or false
Filtered:← Back to module
A
Smoking produces large, reproducible methylation changes at AHRR and F2RL3
EWAS-replicated dozens of times; among the strongest environmental epigenetic signals known.
Module 08 · Lifestyle Inputs to the Epigenome →B
2-year caloric restriction (~12% deficit) slows pace-of-aging biomarkers
CALERIE secondary analysis (Waziry 2023); modest effect, primary endpoints were metabolic.
Module 08 · Lifestyle Inputs to the Epigenome →C
Mediterranean diet produces durable methylation-age reductions
Suggestive evidence (NU-AGE, PREDIMED subanalyses); effect sizes small, replication mixed.
Module 08 · Lifestyle Inputs to the Epigenome →E
Methylated B-vitamin supplementation reduces biological age in non-deficient adults
No RCT support; widespread wellness claim with no rigorous endpoint.
Module 08 · Lifestyle Inputs to the Epigenome →A
Regular aerobic + resistance exercise produces methylation changes at exercise-responsive loci in skeletal muscle
Reproducible across multiple training studies (e.g. Lindholm 2014, Robinson 2017).
Module 08 · Lifestyle Inputs to the Epigenome →