9 modules · Foundations track
Each module includes a foundations explainer, a clinical deep-dive, an advanced research note, claim-graded evidence, and quick-check questions. Switch tracks in the sidebar to unlock different layers.
The Human Genome at Scale
3.1 Gb, 20k coding genes, and ~98% of the action outside them.
Reading the Genome: Platforms & Modalities
Short-read, long-read, optical mapping, single-cell, methylation — what each modality actually sees.
Variant Interpretation: ACMG, VUS, and Penetrance
From a VCF line to a clinical recommendation — the ACMG/AMP framework and where it breaks.
Pharmacogenomics in Practice
CYP2C19, TPMT, DPYD, HLA — when a genotype actually changes prescribing.
Cancer Genomics: Germline, Somatic, and Liquid
Tumor mutation profiles, MRD by ctDNA, and the germline cases that change family screening.
The Epigenome and Methylation Clocks
DNA methylation as the most measurable layer of biological aging — and what it doesn't tell you.
Lifestyle Inputs to the Epigenome
Diet, sleep, exercise, stress — what actually has measurable methylation evidence and what doesn't.
CRISPR Therapeutics: From Casgevy to In Vivo
Cas9, base editors, prime editors — and the 2023 watershed: a CRISPR drug on the market.
Ethics, Equity, and the Germline Question
He Jiankui, returning secondary findings, ancestry bias, and the unresolved policy frontier.