// Evidence Grader
Claim grades, A through F
Every major genomics claim in this course gets a transparent grade — from clinically established interventions to outright misleading marketing. Use this dashboard to audit what's settled, what's preliminary, and what's hype.
A
Clinically established
B
Supported, context-specific
C
Promising, preliminary
D
Plausible, unproven
E
Popular, weak support
F
Misleading or false
Filtered:← Back to module
C
AlphaMissense should be used as primary clinical evidence today
Strong benchmark performance, but ClinGen has not yet defined formal evidence-strength tiers; treat as supporting.
Module 03 · Variant Interpretation: ACMG, VUS, and Penetrance →