// Evidence Grader

Claim grades, A through F

Every major genomics claim in this course gets a transparent grade — from clinically established interventions to outright misleading marketing. Use this dashboard to audit what's settled, what's preliminary, and what's hype.

A
Clinically established
B
Supported, context-specific
C
Promising, preliminary
D
Plausible, unproven
E
Popular, weak support
F
Misleading or false
Filtered:← Back to module
B
PRS adds incremental discrimination on top of pooled cohort equations / QRISK3
Modest C-statistic gain (~0.01–0.02) but meaningful net reclassification at intermediate-risk thresholds.
Module 06 · Polygenic Risk & Early Warning →
B
PRS-guided breast-cancer screening start age improves cancer detection
BCSC + PRS modeling; pilot programs (CanRisk, MyPeBS) ongoing.
Module 06 · Polygenic Risk & Early Warning →