// Evidence Grader

Claim grades, A through F

Every major genomics claim in this course gets a transparent grade — from clinically established interventions to outright misleading marketing. Use this dashboard to audit what's settled, what's preliminary, and what's hype.

A
Clinically established
B
Supported, context-specific
C
Promising, preliminary
D
Plausible, unproven
E
Popular, weak support
F
Misleading or false
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A
Long-read sequencing resolves structural variants missed by short-read WGS
Established across multiple benchmarks; HG002 truthset sensitivity gain is well documented.
Module 02 · Reading the Genome: Platforms & Modalities
A
Native methylation calling on PacBio and ONT is accurate enough to replace bisulfite sequencing
Concordance >95% with WGBS at >5x coverage; saves a sample and is non-destructive.
Module 02 · Reading the Genome: Platforms & Modalities