// Evidence Grader
Claim grades, A through F
Every major genomics claim in this course gets a transparent grade — from clinically established interventions to outright misleading marketing. Use this dashboard to audit what's settled, what's preliminary, and what's hype.
A
Clinically established
B
Supported, context-specific
C
Promising, preliminary
D
Plausible, unproven
E
Popular, weak support
F
Misleading or false
Filtered:← Back to module
A
Roughly 1–2% of the human genome encodes protein
Long established; figure stable across annotations.
Module 01 · The Human Genome at Scale →A
T2T-CHM13 improves variant calling in centromeric and acrocentric regions
Demonstrated across multiple benchmarks (GIAB, T2T consortium 2022).
Module 01 · The Human Genome at Scale →A
Mitochondrial heteroplasmy fraction predicts clinical severity for many mtDNA disorders
Threshold effects well established for MELAS, MERRF, NARP, and Leigh syndrome.
Module 01 · The Human Genome at Scale →